Expression of Concern on “The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients”

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• Expression of concern

The Editor in Chief and the Publisher are issuing an expression of concern regarding the following article:

Minozzi M, Nordio M, Pajalich R. The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients. Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):537-40. PMID: 23467955.

Post-publication concerns have been raised regarding the reliability of certain data and statistical analyses, including possible inaccuracies in the reported p-values, missing ethics approval information, and a potentially undeclared conflict of interest.

The journal contacted the authors requesting clarification and supporting documentation regarding the issues outlined above, but no response has been received despite several follow-up attempts.

The journal has therefore decided to issue this Expression of Concern to alert readers that these matters remain unresolved. Readers are advised to interpret the findings of the article with caution. Further updates will be provided if additional findings emerge from the ongoing investigation.

The Publisher apologizes for any inconvenience this may cause.