Eur Rev Med Pharmacol Sci 2011; 15 (7): 848-850

Acute renal failure and hypercalcemia as onset in splenic lymphoma

M.L. Gasperini, A. Gigante, B. Barbano, M. Liberatori, R. Cianci, A. Amoroso

Department of Clinical Medicine, School of Medicine, Sapienza University, Rome (Italy)


Hypercalcemia is a rare metabolic disorder in course of B cell lymphoma. The mechanism of hypercalcemia in patients with malignancy may include the increased extrarenal production of vitamin D from tumoral cells or neighboring macrophages, i-PTH or PTHrP from tumoral cells. In this case we reported a 34 years old caucasian woman with acute renal failure and hypercalcemia as onset of splenic lymphoma in absence of abnormal levels of serum vitamin D and PTHrP. Because of dramatic recovery of renal function and hypercalcemia after splenectomy, we can speculate that main mechanism of hypercalcemia is related to vitamin D production from neighboring lymphoma macrophages.

Corresponding Author: Antonio Amoroso, MD; e-mail: antonio.amoroso@uniroma1.it

To cite this article

M.L. Gasperini, A. Gigante, B. Barbano, M. Liberatori, R. Cianci, A. Amoroso
Acute renal failure and hypercalcemia as onset in splenic lymphoma

Eur Rev Med Pharmacol Sci
Year: 2011
Vol. 15 - N. 7
Pages: 848-850