Comparison of impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate and phenobarbital

Y.-Y. Wang, M.-G. Wang, D. Yao, X.-X. Huang, T. Zhang, X.-Q. Deng

Department of Neurology, Xuzhou Children’s Hospital, Xuzhou, Jiangsu, P.R. China. dengxingqiang1962@163.com

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• Pharmacology

OBJECTIVE: To study the impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate (TPM) and phenobarbital (PB).

PATIENTS AND METHODS: Two hundred cases children with epilepsy from August 2010 to August 2013 in our hospital were sampled and randomly divided into two groups. The observation group was treated with TPM while the control group with PB, and then comparing seizure frequency, efficiency, and adverse reactions of two groups.

RESULTS: The reduced number of partial seizures, generalized seizures, and total seizures in the observation group were significantly higher than those in the control group, and the rate of cure, markedly effective and total efficiency in observation group were significantly higher than those in the control group. However, the adverse reactions in observation group were significantly lower than those in the control group. Thus, differences were statistically significant (p<0.05).

CONCLUSIONS: Compared with PB, TPM showed a better effect on epilepsy treatment with less adverse reactions which were worthy of clinical recommendation.

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