Predictive value of plasma β2-microglobulin on human body function and senescence

X.-M. Dong, R. Cai, F. Yang, Y.-Y. Zhang, X.-G. Wang, S.-L. Fu, J.-R. Zhang

Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China. j75258249diq@163.com

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• Geriatrics

OBJECTIVE: To explore the correlation between plasma β2-microglobulin (β2-MG) as senescence factor with age, heart, liver and kidney function as well as the predictive value of β2-MG in human metabolism function and senescence.

PATIENTS AND METHODS: 387 cases of healthy people of different ages were selected and the automatic biochemical analyzer was used to test β2-MG in plasma based on immunoturbidimetry and also all biochemical indexes. The correlation between β2-MG and age, gender and all biochemical indexes was analyzed.

RESULTS: β2-MG was positively correlated to age, r = 0.373; and the difference was of statistical significance (p < 0.010). It was significantly negative correlated to HDL-C but positively correlated to LP (a), BUN, CREA, UA, CYS-C, LDH, CK-MB, HBDH, AST, GLB and HCY.

CONCLUSIONS: β2-MG was closely correlated to age, heart, kidney and liver biochemical indexes, which can be taken as an important biomarker for human body function and anti-senescence and have significant basic research and clinical guidance values.

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