Eur Rev Med Pharmacol Sci 2017; 21 (1): 55-60
DOI:

Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells

S. Shen, J.-X. Tang

Department of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, China. sx9l58@163.com

OBJECTIVE: The purpose of this study was to investigate the effect of the heparanase inhibitor OGT2115 on the tumorigenic properties of KB oral cancer cells.

MATERIALS AND METHODS: We treated KB cells with different concentrations of OGT2115. Then proliferation, invasion, and migration were detected using different assays. Cell cycle was explored using flow cytometry.

RESULTS: We found that the treatment inhibited proliferation, invasion, and migration in a dose-dependent manner. OGT2115 also increased the apoptosis of KB cells and blocked cell cycle in S-phase.

CONCLUSIONS: Our results support the use of the heparanase inhibitor OGT2115 to inhibit several tumorigenic activities of KB oral cancer cells.

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To cite this article

S. Shen, J.-X. Tang
Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells

Eur Rev Med Pharmacol Sci
Year: 2017
Vol. 21 - N. 1
Pages: 55-60
DOI:

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