Laminin associated with BMP7 as potential secondary astrocytic glioma fiber differentiation targets

G.-S. Mao, M. Yan, Z.-Z. Ma, L.-Z. Sun, Y. Liu

Departments of Neurosurgery, Chinese People’s Armed Police Force General Hospital, Haidian District, Beijing, China. gengsheng_mao1@163.com

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• Oncology

OBJECTIVE: To investigate the activation of the BMP7 and laminin pathway is associated with glioma cell proliferation and differentiation.

PATIENTS AND METHODS: We enrolled 65 patients with primary operable glioma. Laminin and BMP7 protein expression and its subcellular localization were studied by immunofluorescence.

RESULTS: We detected a higher level of BMP7 expression in glioma tissue in patients with a lower grade of glioma who had a lower eosinophil count. Compared to patients with a higher grade of glioma, we observed a lower level of laminin expression in patients with a lower grade of glioma.

CONCLUSIONS: Our data indicated a potential link between eosinophil counts and the expression levels of laminin and BMP7 in glioma differentiation.

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