Eur Rev Med Pharmacol Sci 2017; 21 (4): 730-741

Defining the biology of intrahepatic cholangiocarcinoma: molecular pathways and early detection of precursor lesions

G. Gibiino, C. Fabbri, S. Fagiuoli, G. Ianiro, A. Fornelli, V. Cennamo

Medical Pathology, Department of Internal Medicine, Gastroenterology Division, Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Rome, Italy. giulia.gibiino@gmail.com

Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of the biliary tract with growing incidence and dismal prognosis. It is responsible for 10-20% of primary liver cancer worldwide, but early diagnosis is still a challenge and few treatment options are available.

Aim of this review is to summarize the current knowledge about biological features and arising molecular patterns of this disease. The identification of emerging biomarkers and early detection of precursor lesions shall play a key role in the perspective of future tailored targeted therapies.

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To cite this article

G. Gibiino, C. Fabbri, S. Fagiuoli, G. Ianiro, A. Fornelli, V. Cennamo
Defining the biology of intrahepatic cholangiocarcinoma: molecular pathways and early detection of precursor lesions

Eur Rev Med Pharmacol Sci
Year: 2017
Vol. 21 - N. 4
Pages: 730-741

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