A meta-analysis of the relations between blood microRNA-208b detection and acute myocardial infarction

W.-Q. Zhang, B.-Q. Xie

Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. dr.boqiaxie@hotmail.com

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• Cardiology

OBJECTIVE: To investigate the relationship between the expression levels of microRNA-208b and early diagnosis of the acute myocardial infarction.

MATERIALS AND METHODS: Literature search were performed within PubMed, Medline, Embase, and CNKI databases, according to inclusion and exclusion criteria, and other relevant literatures about included studies were searched to get more information about this study. Two staff members extracted data from the included studies for meta-analysis.

RESULTS: This study included 6 documents, involving a total of 826 patients with acute myocardial infarction and 429 controls. Meta-analysis results: sensitivity 82%, specificity 83%, positive likelihood ratio of 5.0, negative likelihood ratio 0.21, diagnostic odds ratio area was 23, area under operating characteristic curve was 0.88 (95% CI: 0.85-0.91).

CONCLUSIONS: microRNA-208b expression was increased in the blood of patients with acute myocardial infarction, and may be used for the early diagnosis of acute myocardial infarction molecular biomarkers.

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