Eur Rev Med Pharmacol Sci 2011; 15 (12): 1421-1427

The radiorecovery potential of nutraceuticals in cellular defense after ionizing radiation in vitro

A. Leskovac 1, S. Petrovic 1, A. Valenta-Sobot 1, I. Joksic 2, M. Baltic 3, L. Aleksic 3, G. Joksic 1

1 Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade (Serbia)
2
Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade (Serbia)
3
Oncology Institute of Vojvodina, Sremska Kamenica (Serbia)


Background: The aim of this study was to evaluate the effects of two nutraceuticals Amazon Megamin and Immunarc forte in radiorecovery of human lymphocytes after exposure to ionizing radiation in vitro.

Material and Methods: The incidences of micronuclei, cell proliferation, apoptosis and lipid peroxidation products were examined in cultured human peripheral blood lymphocytes before and after ionizing radiation in a present of nutraceuticals in vitro.

Results: Results showed that Amazon Megamin and Immunarc forte possess antioxidant properties; they act by eliminating the toxic metabolites, scavenging the free radicals and decreasing lipid peroxidation.

Conclusions: The obtained results indicated that the studied nutraceuticals can help in prevention of the development of injurious caused by ionizing irradiation and, therefore, they encourage studies on their radioprotective properties.

Corresponding Author: Gordana Joksic, MD; e-mail: gjoksic@vinca.rs

 

To cite this article

A. Leskovac 1, S. Petrovic 1, A. Valenta-Sobot 1, I. Joksic 2, M. Baltic 3, L. Aleksic 3, G. Joksic 1
The radiorecovery potential of nutraceuticals in cellular defense after ionizing radiation in vitro

Eur Rev Med Pharmacol Sci
Year: 2011
Vol. 15 - N. 12
Pages: 1421-1427