Research on the mechanism of HP mediated PI3K/AKT/GSK3β pathways in gastric cancer

W. Geng, H.-Y. Zhang

Department of Gastroenterology, Daqing Oilfield General Hospital, Daqing, Heilongjiang, China. genwei4225@163.com

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• Oncology

OBJECTIVE: This study aimed to investigate the mechanism of Helicobacter pylori (HP) mediated PI3K/AKT/GSK3β signal pathways in the occurrence of gastric cancer.

PATIENTS AND METHODS: For this purpose, a total of 90 patients were selected; 30 were suffering from gastric cancer and gastric ulcer (observation group I), 30 were suffering from pure gastric ulcer (observation group II) and 30 were with chronic gastritis (control group), and the lesion tissues were extracted by using endoscopy. Then, rapid urease test, RT-PCR and Western blot tests were conducted to detect the positivity rate of HP infection, the expression levels of PI3K/AKT/GSK3β mRNA and protein respectively.

RESULTS: The results showed that the positivity rate of HP infection, expression level of the PI3K/AKT/GSK3β mRNA and protein from the samples of the observation group I were significantly higher than other two groups (p-value <0.05).

CONCLUSIONS: HP may mediate the PI3K/AKT/GSK3β signal pathways in the occurrence of gastric cancer.

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