Significance of interleukin and matrix metalloproteinase in patients with cognitive dysfunction after single valve replacement

H.-Y. Guo

Department of Anesthesiology, the 2nd Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji’nan City, Shandong, China. guo_hongyan1@163.com

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• Pharmacology

OBJECTIVE: To investigate the changes in serum neurological function parameters, interleukin (IL) and matrix metalloproteinase (MMP) in patients with cognitive dysfunction after single valve replacement.

PATIENTS AND METHODS: 51 cases of senile patients with cognitive dysfunction after general anesthesia were selected as the observation group, and 51 senile patients without cognitive dysfunction after general anesthesia were selected as the control group. Serum neurological function parameters and IL and MMP levels were examined and compared between the two groups. The detected levels were also compared among patients with mild, moderate and severe cognitive dysfunction in the observation group. The relationship between these serum biomarkers and postoperative cognitive dysfunction was analyzed.

RESULTS: The serum neurological function parameters and IL and MMP levels were significantly higher in the observation group than those in the control group. Levels in the severe cognitive impairment group were higher than those in the mild and moderate groups, while those in the moderate group were higher than those in the mild group. Logistic analysis showed that the above indices were closely related to postoperative cognitive dysfunction in elderly patients with general anesthesia. The differences between the groups were statistically significant (p < 0.05).

CONCLUSIONS: Elderly patients with postoperative cognitive dysfunction after valve replacement surgery were presented with abnormalities in serum neurological function parameters and IL and MMP levels. There were significant differences in these indices between patients with varying degrees of cognitive dysfunction.

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