Eur Rev Med Pharmacol Sci 2018; 22 (2): 450-455
DOI: 10.26355/eurrev_201801_14194

Regulatory role of CDX2 and NOX4 expression associated with recurrent nasopharyngeal carcinoma

G. Chen, H. Hao, J.-W. Ai

Department of Otorhinolaryngology Head and Neck Surgery, The Beijing Traditional Chinese Medical Hospital Affiliated of Capital Medical University, Beijing, China. chengang01@hotmail.com


OBJECTIVE: Nasopharyngeal carcinoma (NPC) is a malignancy caused by Epstein-Barr virus (EBV). NPC is radiosensitive and has a high frequency of treatment failure due to metastasis, which results in recurrent nasopharyngeal carcinoma (rNPC).

PATIENTS AND METHODS: In the present study, nasopharyngeal carcinoma biopsies were obtained from NPC and rNPC patients, as well as healthy controls, and reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and immunoblotting analyses were performed.

RESULTS: The RTPCR data showed expression of CDX2 and NOX4 in rNPC biopsy samples but not in control or NPC samples. Immunohistochemical and immunoblotting analyses confirmed the expression of CDX2 and NOX4 in rNPC samples, but not in NPC biopsy samples.

CONCLUSIONS: The finding concludes that an association of CDX2 and NOX4 expression with rNPC was noted; thus, these proteins may have value as prognostic indicators and may facilitate the development of novel therapeutics for rNPC patients.

Free PDF Download

To cite this article

G. Chen, H. Hao, J.-W. Ai
Regulatory role of CDX2 and NOX4 expression associated with recurrent nasopharyngeal carcinoma

Eur Rev Med Pharmacol Sci
Year: 2018
Vol. 22 - N. 2
Pages: 450-455
DOI: 10.26355/eurrev_201801_14194