Impact of serum FGF23 levels on blood pressure of patients with chronic kidney disease

J.-X. Li, G.-Q. Yu, Y.-Z. Zhuang

Department of Nephrology, Fuzhou General Hospital, Fujian Province, Fuzhou, China. li_jx1@163.com

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• Nephrology

OBJECTIVE: To investigate the impact of serum FGF23 levels on blood pressure of patients with chronic kidney disease (CKD).

PATIENTS AND METHODS: 128 patients with chronic kidney disease were selected from February 2013 to January 2016. Using CKD staging method, all the patients were divided into 1 to 5 stages according to the glomerular filtration rate. Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect serum FGF23 levels of CKD patients and healthy control subjects. 24 h blood pressure monitoring method was used to monitor the mean arterial pressure of patients. Spearman-related analysis method was used to statistically analyze serum FGF23 level, mean arterial pressure and glomerular filtration rate.

RESULTS: The serum FGF23 levels of CKD patients were significantly higher than those of the healthy control subjects (p<0.05). Also, FGF23 expression levels in serum were positively correlated with mean arterial pressure based on the results of the Spearman-related analysis. On the other hand, FGF23 expression levels in serum were negatively correlated with glomerular filtration rate. The FGF23 expression levels in serum of the patients were significantly decreased along with the decrease of mean arterial pressure.

CONCLUSIONS: Serum FGF23 level is positively correlated with mean arterial pressure and negatively correlated with glomerular filtration rate. So, FGF23 has an important clinical significance that can reflect blood pressure and treatment effect of dialysis of CKD patients.

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