Oral ulcer healing and anti-Candida efficacy of an alcohol-free chitosan-curcumin mouthwash

S. Mahattanadul, M.W. Mustafa, S. Kuadkaew, S. Pattharachayakul, S. Ungphaiboon, K. Sawanyawisuth

Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand. sirima.m@psu.ac.th

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• Pharmacology

OBJECTIVE: The purpose of this study was to investigate oral ulcer healing and anti-Candida efficacy of an alcohol-free 0.1% chitosan-curcumin mouthwash.

MATERIALS AND METHODS: A buccal mucosal ulcer was induced in hamster by topical application of acetic acid. The test mouthwash was applied to the ulcer twice a day for 7 consecutive days beginning on the fourth day after the ulcer induction. The anti-Candida efficacy of the mouthwash was determined against both free floating and biofilm forms of Candida albicans.

RESULTS: The mouthwash significantly decreased the ulcer severity with a better ulcer healing efficacy than that of a standard benzydamine mouthwash. The mouthwash also exerted a comparable anti-Candida efficacy to a standard chlorhexidine mouthwash.

CONCLUSIONS: An alcohol-free 0.1% chitosan-curcumin mouthwash may serve as a safe and potential topical alternative agent in the management of oral inflammatory ulcer and of candidiasis.

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