Correlations of insulin resistance and HbA1c with cytokines IGF-1, bFGF and IL-6 in the aqueous humor of patients with diabetic cataract

H.-C. Zhu, Y. Tao, Y.-M. Li

Department of Ophthalmology, Jining No. 1 People´s Hospital, Affiliated Jining No. 1 People’s Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China. yuanyuanchina2018@gmail.com

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• Ophthalmology

OBJECTIVE: The study aimed to investigate the correlations of insulin resistance and hemoglobin A1c (HbA1c) with cytokines [insulin-like growth factor 1 (IGF-1), basic fibroblast growth factor (bFGF) and interleukin-6 (IL-6)] in the aqueous humor of patients with diabetic cataract.

PATIENTS AND METHODS: 59 patients with diabetic cataract and 58 patients with simple cataract treated in Jining No. 1 People´s Hospital (Jining, China) from January 2017 to February 2018, were selected randomly. The levels of homeostasis model assessment of insulin resistance (HOMA-IR) and HbAlc, as well as IGF-1, bFGF and IL-6 in the aqueous humor were compared between the two groups. The correlations of HOMA-IR and HbAlc with IGF-1, bFGF and IL-6 were analyzed. In control group, the levels of HOMA-IR and HbAlc, as well as IGF-1, bFGF and IL-6 in the aqueous humor were significantly lower than those in observation group (p<0.05).

RESULTS: Compared with the group with HbAlc ≤ 7%, the groups with HbAlc ≥ 9% and 7% <HbAlc< 9% had increased relevant indexes. HbAlc was positively correlated with IGF-1, bFGF and IL-6 (r=0.8309, p<0.001; r=0.8968, p<0.001; r=0.8205, p<0.001). HOMA-IR had positive correlations with IGF-1, bFGF and IL-6 (r=0.9091, p<0.001; r=0.9605, p<0.001; r=0.8118, p<0.001). IGF-1 was positively related to bFGF and IL-6 (r=0.9475, p<0.001; r=0.9112, p<0.001).

CONCLUSIONS: For patients with diabetic cataract, HOMA-IR and HbAlc were associated with IGF-1, bFGF and IL-6 in the aqueous humor. The measurement of those indexes can help to judge the disease conditions accurately, having good predictive value.

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