Eur Rev Med Pharmacol Sci 2020; 24 (18): 9645-9649
DOI: 10.26355/eurrev_202009_23053

Management of hemorrhoidal disease: new generation of oral and topical treatments

C. Ratto, R. Orefice, D. Tiso, G.B. Martinisi, R. Pietroletti

Proctology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy. dottortiso@gmail.com


Hemorrhoidal disease is a widespread proctologic clinical entity. Even if surgical excision is an effective treatment, it only represents the standard procedure for patients with high-grade hemorrhoids. Considering that most cases are grade I or II hemorrhoids, oral or topical therapies are widely used despite, currently, there are no satisfactory options for these kinds of treatments. The pathology involves the degeneration of the supporting tissue of the anal cushions, causing venous dilation, blood stagnation, formation of edematous venous plexus covered by mucosa and inflammation. An effective treatment must, therefore, be multi-targeted and capable of acting on all the pathological mechanisms simultaneously. During the 8th National Congress of the Italian Association of Colorectal Surgery (SICCR), some clinical evidence of hemorrhoidal disease has been discussed along with new opportunities in oral and topical treatment options.

Among these, the effectiveness and the safety of two innovative products, a sublingual nanoemulsion and a liquid bandage, has been reported.

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To cite this article

C. Ratto, R. Orefice, D. Tiso, G.B. Martinisi, R. Pietroletti
Management of hemorrhoidal disease: new generation of oral and topical treatments

Eur Rev Med Pharmacol Sci
Year: 2020
Vol. 24 - N. 18
Pages: 9645-9649
DOI: 10.26355/eurrev_202009_23053