Energy-restricted Central-European diet stimulates liver microsomal function in obese postmenopausal women – a randomized nutritional trial with a comparison to energy-restricted Mediterranean diet

M. Szczepanik, I.J. Malesza, J. Bajerska, A. Chmurzyńska, A. Muzsik, S. Bermagambetova, E. Mądry, J. Walkowiak, A. Lisowska

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland. jarwalk@ump.edu.pl

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• Nutrition

OBJECTIVE: Obesity and metabolic syndrome are risk factors for liver diseases like non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. A healthy food pattern is vital for managing these health problems, therefore, this study investigated how two calorie-restricted diets, the Central European diet (CED) and Mediterranean diet (MED), altered microsomal liver function in obese postmenopausal women with a risk of metabolic syndrome.

PATIENTS AND METHODS: One-hundred-forty-four subjects were randomly assigned to the CED (n=72) or the MED (n=72) groups. A 13C-methacetin breath test was performed, before and after the intervention to assess CPDR (Cumulative Percentage Dose Recovery at 120 minutes of the test), TTP (Time to Peak – maximal momentary recovery of 13C) and Vmax (the maximum momentary 13C recovery).

RESULTS: There was a statistically significant increase in TTP and Vmax in the CED group only (p=0.0159 and p=0.0498, respectively). Changes in CPDR and TTP due to intervention were significantly higher in the CED group than in the MED group (p=0.0440 and p=0.0115, respectively).

CONCLUSIONS: This is the first study to document a stimulatory effect of the energy-restricted CED on liver microsomal function as compared to MED. The relatively short dietary intervention led to a significant difference in the CYP1A2 activity between groups. The trial was registered in the German Clinical Trials Register (DRKS-ID: DRKS00012958; URL: https://www.germanctr.de/).

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