Platelet glycoprotein IaC807T polymorphisms and ischemic stroke in young Chinese Han Population

J. Zhang, D. Huang, J. Yankee, H. An, R. Ojha, C. Du, R. Liu

Department of  Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China. dongyah@hotmail.com

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• Neurology

OBJECTIVES: The objective of this study was to investigate the association between platelet glycoprotein (GP) Ia C807T polymorphisms and ischemic stroke in young Chinese Han Population.

MATERIALS AND METHODS: We conducted a case-control study in 92 consecutive young (</= 50 years) first-ever hospitalized ischemic stroke inpatients and outpatients, 86 elder ischemic stroke control (> 50 years), and 160 age- and sex-matched healthy control. Genotyping of platelet GP Ia C807Tpolymorphisms was performed by polymerase chain reaction followed by sequencing nucleic acid with dideoxy chain-termination method and an ABI PRISM3100 (Perkin-Elmer Co) genetic analyzer. Student’s t-test, chi-square test, and logistic regression modeling were used for data significance analyses.

RESULTS: Hypertension and smoking were found to be the independent risk factors for ischemic stroke patients (aged </= 50 years), while hypertension, diabetes and smoking were the independent risk factors for ischemic stroke patients (aged > 50 years). There was no significant difference observed in the T allele frequency of GPIa C807T polymorphisms between young stroke patients and corresponding controls.

CONCLUSIONS: These findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population.

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