Eur Rev Med Pharmacol Sci 2021; 25 (9): 3530-3535
DOI: 10.26355/eurrev_202105_25835

Vitamin D and iron levels correlate weakly with hepcidin levels in postoperative patients with digestive neoplasms undergoing open abdominal surgery

R. Szabo, C. Petrișor, S. Trancă

Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania. petrisor.cristina@umfcluj.ro


OBJECTIVE: Patients with digestive neoplasms have both iron deficiency and chronic inflammatory anemia with hepcidin upregulation, which may be aggravated in the postoperative period. Vitamin D impacts hepcidin levels. We aimed to investigate the correlations between vitamin D and iron status vs. hepcidin levels in patients with digestive tumors undergoing open abdominal surgery.

PATIENTS AND METHODS: This prospective observational study was performed during 2016-2018 in a University teaching hospital. After obtaining the Ethical Approval and the patients’ informed consent, 30 adult patients with digestive tumors were included. Hepcidin, vitamin D and iron levels were measured in the first 24 hours after surgery.

RESULTS: We observed a negligible/weak correlation between serum iron and hepcidin levels in the first 24 hours after surgery, with a correlation coefficient of 0.24 and a weak/low correlation between hepcidin and vitamin D levels, with a correlation coefficient of 0.37.

CONCLUSIONS: The correlations between vitamin D and hepcidin levels, as well as between hepcidin and serum iron levels, are weak. Interindividual variability in iron-hepcidin-vitamin D regulation might be wide and other regulatory mechanisms might also play important roles in inflammatory anemia modulation in the perioperative period.

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To cite this article

R. Szabo, C. Petrișor, S. Trancă
Vitamin D and iron levels correlate weakly with hepcidin levels in postoperative patients with digestive neoplasms undergoing open abdominal surgery

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 9
Pages: 3530-3535
DOI: 10.26355/eurrev_202105_25835