Eur Rev Med Pharmacol Sci 2021; 25 (1 Suppl): 90-100
DOI: 10.26355/eurrev_202112_27338

Scoping review on the role and interactions of hydroxytyrosol and alpha-cyclodextrin in lipid-raft-mediated endocytosis of SARS-CoV-2 and bioinformatic molecular docking studies

S. Paolacci, A.K. Kiani, P. Shree, D. Tripathi, Y.B. Tripathi, P. Tripathi, G.M. Tartaglia, M. Farronato, G. Farronato, S.T. Connelly, M.R. Ceccarini, M. Coatto, M.C. Ergoren, T. Sanlidag, A. Dautaj, M. Bertelli

MAGI’S LAB, Rovereto (TN), Italy. stefano.paolacci@assomagi.org

OBJECTIVE: The aim of the study was to show the effect that two naturally occurring compounds, a cyclodextrin and hydroxytyrosol, can have on the entry of SARS-CoV-2 into human cells.

MATERIALS AND METHODS: The PubMed database was searched to retrieve studies published from 2000 to 2020, satisfying the inclusion criteria. The search keywords were: SARS-CoV, SARS-CoV-2, coronavirus, lipid raft, endocytosis, hydroxytyrosol, cyclodextrin. Modeling of alpha-cyclodextrin and hydroxytyrosol were done using UCSF Chimera 1.14.

RESULTS: The search results indicated that cyclodextrins can reduce the efficiency of viral endocytosis and that hydroxytyrosol has antiviral properties. Bioinformatic docking studies showed that alpha-cyclodextrin and hydroxytyrosol, alone or in combination, interact with the viral spike protein and its host cell receptor ACE2, thereby potentially influencing the endocytosis process.

CONCLUSIONS: Hydroxytyrosol and alpha-cyclodextrin can be useful against the spread of SARS-CoV-2.

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S. Paolacci, A.K. Kiani, P. Shree, D. Tripathi, Y.B. Tripathi, P. Tripathi, G.M. Tartaglia, M. Farronato, G. Farronato, S.T. Connelly, M.R. Ceccarini, M. Coatto, M.C. Ergoren, T. Sanlidag, A. Dautaj, M. Bertelli
Scoping review on the role and interactions of hydroxytyrosol and alpha-cyclodextrin in lipid-raft-mediated endocytosis of SARS-CoV-2 and bioinformatic molecular docking studies

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 1 Suppl
Pages: 90-100
DOI: 10.26355/eurrev_202112_27338

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