An Italian survey on the use of denosumab for the management of skeletal-related events in patients with bone metastases

R. Berardi, A. Berruti, L. Brogelli, P.A. Zucali

Clinica Oncologica, Università Politecnica delle Marche – AOU Ospedali Riuniti, Ancona, Italy. alfredo.berruti@gmail.com

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• Oncology
• Pharmacology

OBJECTIVE: The Italian Association for Medical Oncology (AIOM) recommends preventive treatment of skeletal-related events in order to improve survival and the quality of life of patients with advanced malignancies. The aim of the study was to evaluate whether routine clinical practice is in agreement with recommendations about the use of denosumab.

PATIENTS AND METHODS: A survey was carried out in Italy in the oncological setting.

RESULTS: The answers to the survey showed that a large proportion of patients with metastases from solid tumors receive treatment; almost all oncologists administered denosumab every 4 weeks but for a shorter period of time than recommended.

CONCLUSIONS: This survey showed that Italian oncologists favor the use of bone-targeted therapy to prevent skeletal-related events in patients affected by metastatic breast, prostate or lung cancer, in agreement with current recommendations.

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