Anti-Leucine-rich glioma-inactivated Protein 1 antibody-associated encephalitis complicated by minimal change nephrotic syndrome: a case report

W.-J. Zhang, N. Gao

Department of Neurology, The First Hospital of Yulin City and The Second Affiliated Hospital of Yanan University, Yulin, Shaanxi Province, China. zhangwj_pumch@163.com

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• Neurology

BACKGROUND: The aim of the study was to summarize the clinical features, diagnosis and treatment of leucine-rich glioma inactivation protein 1 (LGI-1) antibody-associated encephalitis coexistence of minimal change nephrotic syndrome (MCNS), moreover, to strengthen the awareness of the disease. Increasing number of studies describe coexistence of autoimmune encephalitis and other systemic autoimmune diseases.

CASE REPORT: Here we report a case of a patient with anti- LGI1 antibody-associated encephalitis, who presented with cognitive dysfunction, faciobrachial dystonic seizures (FBDS), sleep disturbance, and hyponatremia. Treatment with immunoglobulins, corticosteroids, levetiracetam and oxcarbazepine was proven effective for this patient. The patient had a history of MCNS diagnosed by renal biopsy and responded to treatment with low dose of oral corticosteroids.

CONCLUSIONS: This case expanded the spectrum of autoimmune comorbidities in patients with anti-LGI1 encephalitis.

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