Potentilla bifurca flavonoids effectively improve insulin resistance

G.-Y. Wang, P.-Y. Yan, W. Liu, L.-K. Liu, J.-P. Li, Y. Zeng

College of Life Science, Qinghai Normal University, Xining, China. zy-3@263.net

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• Diabetes
• Phytomedicine

OBJECTIVE: The goal of this paper is to investigate the use of Potentilla bifurca in the treatment of type 2 diabetes.

MATERIALS AND METHODS: We analyzed the improvement effect of 3T3-L1 adipocytes under insulin resistance (IR) with the compounds of Potentilla bifurca.

RESULTS: The Potentilla bifurca can significantly improve the glycolipid metabolism disorder in 3T3-L1 adipocytes (the effect of MC compounds is very significant). It can improve insulin resistance by enhancing the glucose uptake of 3T3-L1 adipocytes, decreasing IL-6 content, and regulating the content of p-Akt/Akt, IKKβ, and p-NF-κBp65/NF-κBp65 in the IRS/PI3K/Akt signaling pathway.

CONCLUSIONS: Studies have shown that Potentilla bifurca has the ability to regulate glucolipid metabolism and can be used in the treatment of type 2 diabetes.

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