Eur Rev Med Pharmacol Sci 2022; 26 (23): 8903-8913
DOI: 10.26355/eurrev_202212_30564

Paclitaxel-resistant related lncRNA DBH-AS1 promotes the proliferation and invasion of esophageal cancer

Z.-X. Lin, L.-H. Zhu, J.-Y. Huang, Y.-Y. Huang, X. Lin

Department of Thoracic Surgery, Fujian Provincial Hospital, Gulou District, Fuzhou, Fujian, China. fzlinxing@163.com


OBJECTIVE: Chemoresistance is one of the main obstacles in the clinical treatment of cancer. However, secondary resistance to paclitaxel poses new challenges for cancer treatment. Long noncoding RNAs regulate cellular functions at different levels and mechanisms and play an important role in the biological behavior of tumors.

MATERIALS AND METHODS: LncRNA microarrays were used to detect lncRNAs in Paclitaxel-resistant cells and corresponding parental cells. Cell counting kit 8 and Transwell analysis were used to test the effect of lncRNA on function.

RESULTS: The expression of lncRNA DBH-AS1 in TE-4 TAX-R cells was significantly higher than that in TE-4 cells. Transwell analysis showed that the overexpression of lncRNA DBH-AS1 increased the invasion of Eca cells. Cell scratches and Transwell analysis showed that the overexpression of lncRNA DBH-AS1 in Eca cell culture supernatants promoted the migration and invasion of HUVEC. In addition, lncRNA DBH-AS1 relies on miR-21 to regulate the expression of YOD1.

CONCLUSIONS: Paclitaxel-resistant lncRNA DBH-AS1 appears to promote ECa cell proliferation and invasion by acting as a ceRNA and regulating miR-21-5p /YOD1 signaling pathway.

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To cite this article

Z.-X. Lin, L.-H. Zhu, J.-Y. Huang, Y.-Y. Huang, X. Lin
Paclitaxel-resistant related lncRNA DBH-AS1 promotes the proliferation and invasion of esophageal cancer

Eur Rev Med Pharmacol Sci
Year: 2022
Vol. 26 - N. 23
Pages: 8903-8913
DOI: 10.26355/eurrev_202212_30564