A meta-analysis of clinical therapeutic effect of insulin glargine and insulin detemir for patients with type 2 diabetes mellitus

Y.G. Zhuang, H. Peng, F. Huang

Department of Emergency, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China. mmherofg@sina.com

 

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• Metabolism

BACKGROUND: Insulin have been recommended to decrease glycosylated hemoglobin (HbA1c) level in type 2 diabetes mellitus (T2DM) patients whose blood glucose control are unsatisfactory by using oral hypoglycemic drugs.

AIM: To systematically estimate the therapeutic effect and security of insulin glargine and insulin detemir for treatment of type 2 diabetes mellitus.

MATERIALS AND METHODS: We searched the Cochrane library, PubMed, EMBASE, etc databases. Quality evaluation of all randomized control tests (RCT) enrolled was conducted according to Cochrane manual, and meta-analysis was performed by using RevMan5.0 software.

RESULTS: Both insulin glargine and insulin detemir can effectively control T2DM patient’s blood glucose.

CONCLUSIONS: Insulin detemir has evident superiority on reducing body weight than insulin glargine. As the doses are concerned, daily insulin dose of insulin detemir is higher than insulin glargine.

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