Relation of –55CT polymorphism of UCP3 gene with weight loss and metabolic changes after a high monounsaturated fat diet in obese non diabetic patients

D.A. De Luis, R. Aller, O. Izaola, B. De La Fuente, R. Conde, J.M. Eiros Bouza

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es

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• Metabolism

AIMS: The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene on metabolic response, weight loss and serum adipokine levels to a high monounsaturated fat hypocaloric diet in obese patients.

PATIENTS AND METHODS: A sample of 128 obese patients was analyzed in a prospective way during 3 months.

RESULTS: Eighty eight patients (21 males/67 females) (68.8%) had the genotype 55CC (wild genotype group) and 40 patients (8 males/32 females) (31.3%) 55CT (mutant genotype group). In wild genotype group, BMI (–1.6±1.3 kg/m2), weight (–4.3±3.7 kg), fat mass (–3.5±3.3 kg), waist circumference (–5.1±2.9 cm), total cholesterol (–7.2±10.6 mg/dl), LDL cholesterol (–5.3±12.8 mg/dl) and leptin (–4.7±10.1 ng/ml) decreased. In mutant genotype group, BMI (1.3±2.2 kg/m2), weight (–3.0±1.4 kg), fat mass (–2.5±1.1 kg), waist circumference (–2.8±3.1 cm) and leptin (–5.8±10.7 decreased.

CONCLUSIONS: In patients with –55CC UCP3 genotype, a high mono-unsaturated hypocaloric diet reduced BMI, weight, waist circumference, waist to hip ratio, fat mass, LDL-cholesterol, total cholesterol and leptin levels. Carriers of T allele had a different response than –55CC patients, with a significant decrease of the same antropometric parameters, but lower than in the wild genotype group, and without significant changes in cholesterol levels.

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