Urethane suppresses renal sympathetic nerve activity in Wistar rats

G.f. Wang, X.j. Mao, Z.j. Chen

Department of Anesthesiology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China. gengfuwang@yeah.net

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• Pharmacology

AIM: To investigate the effects of urethane on renal sympathetic nerve activity (RSNA) in Wistar rats.

MATERIALSAND METHODS: 46 rats were randomly allocated in two groups: group A in which rats were injected with urethane; group B in which barbital sodium was used as a control. The changes of RSNA, blood pressure (BP) and heart rate (HR) of each group were evaluated and analyzed.

RESULTS: Compared to the control group, the value of RSNA, BP and HR were all significant decreased in rats of group A after urethane injection (p < 0.05).

CONCLUSIONS: These results suggest that urethane could affect RSNA through somatosensory system.

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