Relationship between adiposity, adipokines, inflammatory markers and lipid profile in hemodialysis patients

A. Markaki, K. Gkouskou, K. Stylianou, E. Dermitzaki, K. Perakis, A. Margioris, E. Daphnis

School of Medicine, University of Crete, Crete, Greece. gkouskou@imbb.forth.gr

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• Nephrology

OBJECTIVES: Our aim is to study the correlations of leptin and adiponectin with inflammation markers, body composition and lipid profile in end stage renal disease (ESRD) patients.

PATIENTS AND METHODS: Phase angle values and fat mass as calculated using BIA, Malnutrition-Inflammation Score (MIS), leptin, adiponectin, IL-6, IL-8 triglycerides, cholesterol and other common serum markers’ concentrations were analyzed using simple and multiple linear regression models in 47 hemodialysis patients.

RESULTS: In contrast to leptin, adiponectin is inversely correlated to BMI and fat mass in hemodialysis patients. Triglycerides were the only parameter that retained its statistical correlation significance with adiponectin in the multiple regression model.

CONCLUSIONS: Fat mass is of important consideration when calculating adipokines levels and their possible correlations with other variables. The inverse correlation of adiponectin with triglycerides levels should be further delineated due to the important role of vascular diseases in total mortality and morbidity of ESRD patients.

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