Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory?
G. Gravante, S. Yahia, K. Gopalakrishnan, G. Mathew Department of Surgery, and Department of Histopathology, George Eliot Hospital, Nuneaton, United Kingdom. ggravante@hotmail.com
Associations of various histotypes in appendiceal neoplasms may help elucidate the histogenesis of such uncommon tumors. We present the fourth published case of Goblet Cell Carcinoid (GCC) associated with mucinous adenocarcinoma of the appendix. This association has been described only for GCC and not for classic appendix carcinoids which are thought to originate from neuroendocrine-committed cells. The GCC-mucinous association adds more towards the theory of a pluripotent intestinal stem cell with amphicrine possibilities of differentiation.
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G. Gravante, S. Yahia, K. Gopalakrishnan, G. Mathew
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory?
Eur Rev Med Pharmacol Sci
Year: 2014
Vol. 18 - N. 11
Pages: 1591-1594