Eur Rev Med Pharmacol Sci 2010; 14 (5): 435-441

Role of exogenous melatonin on adriamycin-induced changes in the rat heart

S. Aydemir, I. Özdemir*, A. Kart**

Division of Biology and *Department of Biochemistry, Faculty of Science, Inönü University, Malatya (Turkey); **Department of Pharmacology and Toxicology College of Veterinary Medicine, University of Kafkas, Kars (Turkey)


Abstract. – Aim: The protective effect of melatonin on adriamycin (ADM)-induced cardiotoxicity was investigated in the rat heart. Melatonin is a pineal hormone with free radical scavenging activity on oxidants; therefore it may decrease the ADM-induced oxidative stress and cardiotoxicity so that therapeutic efficacy might be enhanced.
Materials and Methods: Wistar rats in 4 groups were treated with saline (control), melatonin (MEL), adriamycin (ADM) and melatonin plus adriamycin (MEL+ADM).
Results: Adriamycin given at a single dose of 15 mg/kg significantly increased lipid peroxidation products as measured by thiobarbituric acid reactive substances (TBARS). Melatonin (5 mg/kg bw) given 2 days before and 7 days after ADM treatment reduced TBARS level. Adriamycin significantly reduced superoxide dismutase activity which was elevated by melatonin treatment. Additionally, ADM significantly increased catalase enzyme activity while melatonin normalized the ADM induced alteration in activity of catalase.
Conclusions: The combined use of ADM and melatonin reduces the threat of cardiomyopathy. Melatonin seems to hold promise as a therapeutic treatment and can be recommended as an adjunct in antitumor therapy as a safe and effective protection against acute ADM-induced cardiotoxicity.

Corresponding Author: Songul Aydemir, MD; e-mail: e-mail:

To cite this article

S. Aydemir, I. Özdemir*, A. Kart**
Role of exogenous melatonin on adriamycin-induced changes in the rat heart

Eur Rev Med Pharmacol Sci
Year: 2010
Vol. 14 - N. 5
Pages: 435-441