Eur Rev Med Pharmacol Sci 2010; 14 (8): 653-660

Synthesis of novel naphthyl substituted fused indazolonols as potent anticandidal agents

V. Kanagarajan, J. Thanusu, M. Gopalakrishnan*

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu (India)


Abstract. – Objectives: A new series of naphthyl substituted indazolonols 15-21 were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1H, D2O exchanged 1H and 13C NMR spectroscopic data.
Methods: All the synthesized compounds 15-21 were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilosis.
Results: A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH3 and OCH3) and electron withdrawing (-F, -Cl, Br and -NO2) functional group substituted phenyl rings of novel naphthyl substituted indazolonols 15-21 exerted strong anticandidal activity against all the tested Candida species.
Conclusions: Compounds 17, 19-21 exhibit MIC value in the range of 6.25-200 µg/mL against all the tested candida species.

Corresponding Author: Mannathusamy Gopalakrishnan, Ph.D; e-mail: profmgk@yahoo.co.in

To cite this article

V. Kanagarajan, J. Thanusu, M. Gopalakrishnan*
Synthesis of novel naphthyl substituted fused indazolonols as potent anticandidal agents

Eur Rev Med Pharmacol Sci
Year: 2010
Vol. 14 - N. 8
Pages: 653-660