Herbal hepatotoxicity: a case of difficult interpretation

G. Valente, M. Sanges, S. Campione*, C. Bellevicine*, G. De Franchis, R. Sollazzo, D. Mattera, L. Cimino, R. Vecchione*, A. D’Arienzo

Gastroenterology Unit, Federico II University, Naples (Italy); *Department of Biomorphological Science, Federico II University, Naples (Italy)

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• Phytomedicine

Herbal medicines are widely used in the world and are generally considered effective and safe, although many studies have demonstrated their potential toxic effects, particularly for the liver. We present a case of a woman, who developed a mixed cholestatic/hepatocellular liver injury due to herbal products. Firstly, she was admitted to Division of Surgery for right upper abdominal pain and jaundice and, for the suspect of biliary obstruction, she underwent to cholecystectomy. For persistence of liver enzymes elevation, she was admitted to our Gastroenterology Unit. We excluded every etiologies of hepatitis and, after an intensive dialogue with the patient, we obtained a history of herbal medicines use. Then, we performed a liver biopsy which was compatible with hepatotoxic injury. Therapy with ursodeoxycholic acid (UDCA) was started. Liver function tests returned to normal in two months. We describe this clinical case to encourage the communication doctor/patient in phytotherapy area and physician knowledge about efficacy and side effects of herbal medicine to avoid delayed diagnosis.

Corresponding Author: Marco Sanges, MD; e-mail: marcosanges1974@libero.it