RTN4/Nogo is an independent prognostic marker for gastric cancer: preliminary results

C. Chi, N. Liu, L. Yue, W.-W. Qi, L.-L. Xu, W.-S. Qiu

Department of Oncology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China. wenshengqiu22@126.com

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• Oncology

OBJECTIVE: Gastric cancer is the fourth most common malignant cancer and is the second leading cause of cancer death worldwide. We evaluated the association of the immunohistochemical RTN4 expression with clinicopathological variables and patient outcome, and to evaluate its prognostic value.

PATIENTS AND METHODS: Histological samples from 95 primary gastric carcinoma patients were retrospectively studied with monoclonal antibody to RTN4.

RESULTS: Tumors with high RTN4 expression were found in 57.9% of patients. High RTN4 were associated with advanced stages (p = 0.0377) and different histology (p = 0.0030). In the overall population (median follow-up 42 months), patients with high RTN4 had shorter survival time than those with low RTN4 expression (p = 0.0119). In Cox multivariate analysis, high RTN4 (p = 0.0160) is an independent prognostic factor for overall survival of gastric cancer patients.

CONCLUSIONS: Our data suggest that RTN4 may contribute to the malignant progression of gastric cancer and serve as a novel prognostic indicator for gastric cancer patients.

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