Analysis on the correlation factors for hemorrhagic transformation after intravenous thrombolytic therapy

P.-L. Zhang, Y.-X. Wang, Y. Chen, C.-H. Zhang, C.-H. Li, Z. Dong, S.-S. Zhang, Y.-F. Tong, Y.-Q. Li, X.-G. Tong, J.-H. Wang

Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin, China. peilanzhng@sina.com

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• Neurology

OBJECTIVE: To examine the correlation factors for hemorrhagic transformation after intravenous thrombolytic therapy, so as to improve the forecast about hemorrhagic transformation in the process of thrombolysis, and provide theoretical basis for prognosis of the patients.

PATIENTS AND METHODS: A total of 1223 patients with intravenous thrombolytic therapy including NIHSS score before intravenous thrombolytic therapy and MRS score by follow-up of three months after intravenous thrombolytic therapy were enrolled in this study, and related clinical data were collected. t test, χ2 test and logistic regression analysis were used to find the correlation factors for hemorrhagic transformation.

RESULTS: Single-factor analysis found hypertension, diabetes mellitus, history of stroke and collateral circulation insufficiency had statistical significances between each type of hemorrhage group groups. Amongst of the history of hypertension, diabetes and stroke was correlation factor for prognosis.

CONCLUSIONS: Intravenous thrombolysis hemorrhagic transformation associated with these factors including the vessel wall, blood composition and biochemical markers.

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