Eur Rev Med Pharmacol Sci 2015; 19 (7): 1272-1275

Adequacy of peritoneal dialysis: Kt/V revisited

L. Wang, T. Wang

Department of Internal Medicine, Jiangsu Xuzhou First People’s Hospital, Xuzhou, China. lingw1228@sohu.com


OBJECTIVE: Kt/V urea has been used to assess adequacy of peritoneal dialysis. However, Kt/V urea only reflects the clearance of solute without taking into consideration the effects of dietary protein intake (DPI). The objective of this study is to evaluate the value of Kt/V based on nitrogen balance and to observe if it is the best adequacy index.

METHODS: On the premise that nitrogen balance is obtained, we calculated the minimal adequate dialysate volume and dialysis index (DI), Kt/V and solute removal index (SRI). We compared the values of DI, Kt/V and SRI to evaluate the adequacy of peritoneal dialysis.

RESULTS: Kt/V was changed with DPI and body weight of continuous ambulatory peritoneal dialysis (CAPD) patients. We cannot define adequate dialysis with a single value while DPI and body weight are different since CAPD, SRI and Kt/V are numerically equal. However, dialysis index (DI) can reflect the minimal adequate dialysate volume when DPI and body weight are different and, thus, reflects the adequacy of dialysis.

CONCLUSIONS: DI reflects the balance between DPI and solute clearance; thus, it is more useful to evaluate dialysis adequacy than Kt/V and SRI in clinically stable peritoneal dialysis patients.

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To cite this article

L. Wang, T. Wang
Adequacy of peritoneal dialysis: Kt/V revisited

Eur Rev Med Pharmacol Sci
Year: 2015
Vol. 19 - N. 7
Pages: 1272-1275