Analysis of the treatment of gliomas with SEC therapy combined with radiochemotherapy

F. Wang, Q. Huang, L.-Y. Zhou

Department of Brain Tumor Research, No. 2 Hospital of Suzhou University, Suzhou, China. wangfan1965@sina.com

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• Oncology

OBJECTIVE: To investigate the anti-glioma effects of staphylococcal enterotoxin C (SEC) combined with surgery, radiotherapy and chemotherapy, and the IL-2 of lymphocytes activated by SEC.

PATIENTS AND METHODS: A total of 92 patients with gliomas which had been surgically removed, were randomly divided into a control, and treatment groups A (systemic application of SEC) and B (local application of lymphocytes activated by SEC). The treatment effects were observed on a CT scan of the head. The SEC’s induction on the IL-2 secretion by lymphocytes was determined using immunohistochemistry and RT-PCR methods.

RESULTS: Clinical materials showed that the effective rate (CR and PR) in the control group was 32.0%. In the treatment group A, the effective rate was 51.6% and 63.6% in the group B. The IL-2 of lymphocytes secreting activity activated by SEC began to secrete IL-2 on the 1st day and reached a peak during the 3rd day and the 5th day.

CONCLUSIONS: As a superantigen, SEC combined with surgery, radiotherapy and chemotherapy can improve treatment. The lymphocytes activated by SEC can release IL-2.

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