Eur Rev Med Pharmacol Sci 2015; 19 (17): 3303-3308

Resveratrol caused apoptosis in QGY-7701 cells

J.-P. Li

Department of Oncology, People’s Hospital of Xintai City, Affiliated to Taishan Medical University, Xintai, Shandong Province, P. R. China.

OBJECTIVE: This study aims to evaluate the cytotoxicity of resveratrol in QGY-7701 cells using a cell viability assay and determine genetic damages after 24-h exposure to concentrations of 6, 12, and 24 µmol·L-1.

MATERIALS AND METHODS: Cell viability and genetic damages were determined using a WST-1 assay and Hoechst 33342 staining with single cell gel electrophoresis (SCGE), respectively. Reactive oxygen species (ROS) levels were also determined.

RESULTS: The results demonstrated that resveratrol inhibited QGY-7701 cell growth and decreased their viability in a dose-dependent manner. Furthermore, resveratrol caused nuclear morphological changes and DNA damage, promoted ROS levels, and induced cell apoptosis.

CONCLUSIONS: These results suggest that resveratrol may induce QGY-7701 cell apoptosis by triggering excessive ROS generation and DNA damage.

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To cite this article

J.-P. Li
Resveratrol caused apoptosis in QGY-7701 cells

Eur Rev Med Pharmacol Sci
Year: 2015
Vol. 19 - N. 17
Pages: 3303-3308