Prognostic significance of flow cytometry findings in Turkish adult acute leukemia patients

A. Basturk, S. Akinci, T. Hacibekiroglu, T. Guney, A. Kutlucan, F. Ceran, S.D. Akalin, S.M.B. Ozturk, H. Okutan, G. Ozet, I. Dilek

Division of Hematology, Department of Internal Medicine, Konya Research and Training Hospital, Konya, Turkey. drbasturk@yandex.com

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• Hematology

OBJECTIVE: Several factors are known to affect prognosis of acute leukemia such as age, high leukocyte count, cytogenetic abnormality, performance status and recurrent leukemia.
We aimed to investigate the association between cell surface markers and prognostic determinants such as recurrence at 6 and 12 months and survival at 6, 12 and 18 months in acute leukemia patients.

PATIENTS AND METHODS: A total of 142 patients, 101 with acute myeloid leukemia (AML) and 41 with B-cell acute lymphoblastic leukemia (B-ALL) were included. The effects of surface markers on survival and recurrence rates were evaluated retrospectively.

RESULTS: In AML patients, CD5+ and CD34+ immunophenotypes and in ALL patients cCD22+, CD34+ and CD49f + CD19+ immunophenotypes were positive prognostic indicators. In AML patients CD7 expression, and in ALL patients CD5+, CD7+ and CD117+ immunophenotypes and >90% CD45 expression were negative prognostic indicators.

CONCLUSIONS: This study demonstrates that flow cytometry, a common diagnostic tool in acute leukemia, may also have prognostic value in acute leukemia in the future.

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