The study of the relationship between aberrant expression of hot shock protein 70 (HSP70) and spontaneous abortion

Y.-B. Peng, H. Liu, S.-H. Huang, H. Lai, Q. Zhou, Y. Luo, Z.-Y. Zhang, B.-R. Xi, X. Ouyang

Medical College of Nanchang University, Nanchang, Jiangxi, P.R. China. huai_liu1@163.com

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• Obstetrics

OBJECTIVE: The present study is aimed to explore the relationship between aberrant expression of heat shock protein 70 (HSP) and spontaneous abortion.

PATIENTS AND METHODS: 50 patients with spontaneous abortion and 50 patients with induced abortion were continuously selected based on the nearest matching principle, and the proportion of age and gestational age was 1:1. The decidual tissues were obtained, and the cell apoptosis was determined by TUNEL assay. Further, the expression of HSP70 was assayed by immune-histochemical staining, and the expression of HSP70 mRNA was detected by the RT-PCR approach.

RESULTS: Apoptosis rate, HSP70 expression and HSP70 mRNA expression in the observation group were significantly higher than the control group.

CONCLUSIONS: HSP70 might induce apoptosis so as to cause spontaneous abortion.

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