Eur Rev Med Pharmacol Sci 2010; 14 (7): 639-642

Melkersson-Rosenthal syndrome associated with Down syndrome

M. Greco, M.A. Fiorillo, D. Ribuffo*, A. Corona*, T. Vitagliano

Department of Plastic and Reconstructive Surgery, University “Magna Graecia” of Catanzaro (Italy) *Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Cagliari (Italy)


We present a clinical case of Melkersson-Rosenthal (M-R) syndrome associated with Down syndrome. No evidence of this association is described in the literature. We also present a technique for the macrocheilia treatment of lower lip caused by M-R syndrome in a patient with Down syndrome. This patient during pediatric age had many events of facial nerve paralysis and edematous episodes of lower lip with unknown etiology. This technique is based on a wedge full thickness central excision of the lower lip and on a transversal lozenge excision in the vermilion portion with orbicular muscle to reverse the chin-labial corner. The results are an agreeable aspect of the lip and physiological digestive and phonetic processes. The technique is safe and simple and the aesthetic functional result is very good. In our case, the postoperative complication is caused by an insufficient collaboration of the patient and it is solved in three weeks.

Corresponding Author: Manfredi Greco, MD; e-mail: manfredigreco@unicz.it

To cite this article

M. Greco, M.A. Fiorillo, D. Ribuffo*, A. Corona*, T. Vitagliano
Melkersson-Rosenthal syndrome associated with Down syndrome

Eur Rev Med Pharmacol Sci
Year: 2010
Vol. 14 - N. 7
Pages: 639-642