Non-extracorporeal circulation for coronary artery bypass graft surgery is more beneficial than extracorporeal circulation

F.-Y. Yang, Y.-Z. Bao, F.-S. Liu, Y.-C. Zhu, J. Zheng, J.-H. Zhang, X.-F. Zheng, G.-C. Wei

Intensive Care Unit, The People’s Hospital of Laiwu City, Laiwu, Shandong Province, China. drweiguangchen@163.com

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• Cardiology

OBJECTIVE: The objective of this study was to compare coronary artery bypass graft (CABG) surgery with non-extracorporeal vs. extracorporeal circulation. The study outcomes included operative time, number of graft vessels, pulmonary infection rates, and systemic inflammatory markers.

PATIENTS AND METHODS: 96 patients received selective CABG, either with non-extracorporeal (study group; n = 48) or extracorporeal circulation (control group; n = 48). Operative time, pulmonary infection rates, and blood levels of inflammatory markers TNF-α, IL-6, and IL-8 before and 4, 24, and 48 hours after the surgery were quantified. Graft vessels were quantified using computed tomography.

RESULTS: Operative time was significantly shorter in study group (4.58 ± 0.91 vs. 5.36 ± 1.12 hours in control group; p < 0.05). The number of graft vessels and pulmonary infection rates were comparable between both techniques. However, systemic inflammatory markers were significantly (p < 0.05) lower in study group at 4 and, partly, 24 hours after the surgery.

CONCLUSIONS: Extracorporeal circulation prolongs operation and can aggravate systemic inflammatory response. Therefore, CABG with non-extracorporeal circulation offers more beneficial outcomes.

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